Unlocking pain relief for millions of women worldwide
Localized provoked vulvodynia (LPV) is a chronic condition impacting more than one in ten women at some point in their lives. It results in severe vulvar pain and often leads to additional health issues, such as depression, anxiety and fertility problems. Given the prevalent nature of the condition and lack of adequate treatment available on the market, we embraced the challenge of utilizing the unique properties of maresins to aid in the resolution of vulvodynia inflammation.
With robust preclinical science demonstrating the role of maresins in relieving vulvodynia-related pain and inflammation, we are now in the process of conducting clinical trials to develop an efficacious and highly-targeted maresin-based treatment for LPV.
1 B.L. Harlow, E.G. (2003) Stewart, A population-based assessment of chronic unexplained vulvar pain: have we underestimated the prevalence of vulvodynia? J. Am. Med. Wom. Assoc. 58 (2) 82–88.
2 Xie Y, Shi L, Xiong X, Wu E, Veasley C, Dade C. (2012) Economic burden, and quality of life of vulvodynia in the United States. Curr Med Res Opin. 28(4).
3 Press Release (2024): Global Vulvodynia Treatment Market Set to Exceed USD 8 Billion by 2028, Driven by Advancements in Pain Management and Therapeutic Approaches. Pharmiweb.com. Available at: Global Vulvodynia Treatment Market Set to Exceed USD 8 Billion by 2028, Driven by Advancements in Pain Management and Therapeutic Approaches - PharmiWeb.com
4 Graziottin A, Murina F, Gambini D, Taraborrelli S, Gardella B, Campo M; VuNet Study Group. (2020) Vulvar pain: The revealing scenario of leading comorbidities in 1183 cases. Eur J Obstet Gynecol Reprod Biol. 252:50-55.
Our mission to develop a disruptive treatment for LPV is making significant progress, with several important milestones already achieved.
Demonstrated significant efficacy of MaR1-derived compound (MaR102) in animal models
Demonstrated safety of MaR102 in various animals species and with different administration modes
Finished development of GMP-compliant manufacturing process for MaR102 drug substance and formulation
Successfully conducted Pre-Investigational New Drug (IND) meeting with the Food and Drug Administration (FDA)
Completed the preparation for our first clinical trial: a Phase 1/2a study of topical MaR102 in women with LPV to demonstrate both product safety and efficacy