Forging the future of pain relief

WE ARE SPM THERAPEUTICS

The only company developing disruptive treatments for detrimental inflammation and pain by harnessing the natural power of maresin compounds. Our innovative approach leverages the unique properties of these advanced anti-inflammatory compounds to stimulate the body’s natural resolution of inflammation while simultaneously blocking pain signaling.

Our unique compounds, licensed from Harvard University, combined with our clinical expertise and synergistic drug development programs, make us the partner of choice for companies seeking to elevate their portfolios with truly unique formulations. Together with our leading market experience, we can pioneer a new frontier of life-changing therapeutics that stop chronic inflammation at its source.

What are MARESINS?

Maresins are naturally occurring lipids that form part of the group of Specialized Pro-resolving Mediators (SPMs). Recent breakthrough science reveals that SPMs, including maresins, are critical components of the inflammation resolution machinery.

Stopping chronic inflammation and pain at its source

Inflammation is a physiological response necessary to protect the body from infections and injuries. However, if it is not properly resolved, inflammation can have a detrimental effect on health - causing pain and potentially leading to the development of chronic disease. Stopping the root cause of inflammation is key to solving this problem. That’s where maresins come in.

Maresins compounds have demonstrated powerful anti-inflammatory and analgesic properties, relieving pain while promoting tissue health and recovery to support disease resolution – at its source.1 This opens doors of opportunity to expand treatment options for patients suffering from diseases caused or amplified by uncontrolled inflammation, such as vulvodynia, cancer, autoimmune diseases and neurological diseases.

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exploit the natural healing power of maresins

Targets inflammation

Maresin 1 (MaR1) acts on the root cause of inflammation by stimulating the body’s natural resolution process

Blocks pain

MaR1 blocks peripheral and central pain signaling pathways7

Powerful pain relievers

SPMs act as more powerful pain relievers than opioids8

Fewer negative side effects

MaR1 is non-immunosuppressive and non-addictive8

Superior safety profile

MaR1 have a superior safety profile compared to traditional anti-inflammatories

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Targeted relief for chronic conditions  

In various animal models, maresins have shown to have a powerful, and safe potent, positive impact on inflammation and pain associated with several conditions, including vulvodynia. There is currently no approved medication on the market for vulvodynia. SPM Therapeutics is preparing a clinical trial with its topical formulation containing MaR1 pro-drug for testing it in vulvodynia patients.

Maresins compounds have also shown promising potential in treating lupus, as well as skin-related diseases, such as vitiligo, psoriasis and atopic dermatitis. SPM Therapeutics has drug development programs for these indications too. They have also shown promising potential in treating vulvodynia, which currently has no approved medication on the market. Clinical demonstration for vulvodynia is on its way.

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Leaders in targeting inflammation and pain at the source

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